This seems rather interesting to me. I've always enjoyed the somewhat Star Trek nature of the corporate explorers or the expeditionary corps back on Bay but I think this is a very interesting setting. It reminds me pretty closely of Traveller which, not sure if it's an inspiration, but it strikes me as "very large roleplay group sets out on a Free Trader and hijinks ensue", and it's one of my favorite RPGs and settings.
I've always been a bit curious about the medical rework, as I've seen it mentioned a few times in the past. Is there a dedicated document to that somewhere? It's certainly something I've been interested in contributing to if I can find the time, whenever that time comes