I don't think it should be harder on the cloned person. Well, maybe a bit just to help teach them not to run out and die all the time. But, if the resources to clone were more limited and harder to come by that would greatly slow down the amount of clones coming out of medbay.
I would say some disabilities for a clone could be great for RP, for example: anything from the genetics disabilities list, weak muscles from being freshly cloned and need walking assistance for a while, or maybe a missing limb in extreme cases.
Limiting the amount of clones possible by starving the machine of resources would make the geneticist have to choose who has more priority of being cloned and if those resources are harder to come by they may be out of the game for quite awhile if not the entire round.
