Awesome changes, makes me want to get back into medical.
It's just the OD for Inaprovaline, Dylovene and Tricordrazine that seem painfully low, though there is no telling how it will play out in-game and at least the side effects are manageable. They were basic, beginner level drugs & are pretty readily available. Two of them did not even have an OD previously, so of the changes these are the only ones that worry me. 30 or 40 would be far more forgiving (if only for Dylo and/or Tricord), especially since all of the changes will probably take a lot of adjustment already.