For me I guess it depends on if it's an important element for a lore detail. Are uplifted Secondaries a key aspect of Dominian lore or just a potential character concept someone could have? If the latter, wanting a specific accent for a specific scenario sort of opens the door to a sort of limitless selection of cross accents which seems in my opinion to be over the top. If the former then it makes sense since that's what accents are for, and the argument against them could be made for accents in general (just flavour text them).
Are uplifted Secondaries intrinsic to Dominia lore?